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The aim of this study is to investigate the effect of a non-invasive physical treatment on activated microglia of a well-established mouse model of Parkinson disease (PD), based on intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). To this aim, we proposed a Radio electric asymmetric conveyer (REAC) technology, with its specific therapeutic protocols of regenerative medicine: tissue optimization - regenerative (TO-RGN), as an innovative therapeutic strategy for the treatment of PD. We observed that REAC TO-RGN exposition can attenuate the damage of nigrostriatal pathway induced by MPTP treatment in mice, decreasing levels of pro-inflammatory mediators in the substantia nigra pars compacta (SNpc) of MPTP-mice. Besides, TH immunostaining in MPTP-treated mice exposed to REAC TO-RGN resulted more pronounced in both substantia nigra and striatum in comparison to animals that …
Publication date: 
1 Jan 2015

Maria Antonietta Panaro, Vito Carofiglio, Rosa Calvello, Alessandra Aloisi, Rosaria Rinaldi, Giuseppe Nicolardi, Dario Domenico Lofrumento, Francesco De Nuccio, Velia La Pesa, Vania Fontani, Salvatore Rinaldi

Biblio References: 
Pages: 1-4
2015 IEEE 15th Mediterranean Microwave Symposium (MMS)