Purpose Although no cure is available, cognitive rehabilitation (CR) for patients with mild1 Alzheimer's disease (AD) appears to be an attractive treatment. In the last two years many technical solutions, such as serious games, have been studied for cognitive assistance2, 3. However, most of these initiatives (including commercial products such as Nintendo's Brain Age and Big Brain Academy) provide only memory challenges or random puzzles that are to be played a few minutes per day with the purpose of" improving brain performance". The objective of this work is the design and development of an Information and Communication Technology (ICT) platform that integrates advanced Natural User Interface (NUI) technologies for multi-domain cognitive rehabilitation (temporal and spatial orientation, visual and topographical memory, verbal memory and fluency, visual and hearing attention, etc.). Method The platform …