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6-[18F]fluoro-3,4-dihydroxyphenylalanine ([18F]F-DOPA) is a diagnostic positron emission tomography agent, widely used in imaging the loss of dopaminergic neurons in Parkinson’s disease and, recently, to detect, stage and restage neuroendocrine tumors and to search for recurrence of viable glioma tissue.In this paper, we establish a protocol of thermal aging (i.e., heating timescales of the order of 24 h and temperatures higher than 120 °C) against the swelling and morphological surface degradation (inspected by microscope imaging) of poly(dimethylsiloxane) (PDMS) by dichloromethane (DCM) and hydriodic acid (HI), that are chemicals involved in the microfluidic synthesis of [18F]F-DOPA. Swelling tests on PDMS channels heated at 150 °C (for 24 and 48 h) and 180 °C (for 24 h) confirm a percentage change of the channel dimension as low as 2–8% after loading with DCM. Also, X-ray photoelectron …
Publication date: 
1 Jan 2018

Maura Cesaria, Valentina Arima, Simona Rella, Cosimino Malitesta, Maria Concetta Martucci, Maria Grazia Manera, Anna Tolomeo, Antonio Scilimati, Roberto Rella

Biblio References: 
Volume: 254 Pages: 143-152
Sensors and Actuators B: Chemical