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Leukemia is a group of cancers that usually begin in the bone marrow and result in high numbers of abnormal and dysfunctional white blood cells. Many studies were carried out to investigate metabolism of these cells. Metabolome analysis has been successfully applied to leukemia disease and emerged as a powerful tool for obtaining information about the biological processes that occur in organisms, and as a useful platform for discovering new clinical biomarkers and make diagnosis of disease using different biofluids. Whatever has not been investigated in leukemic cells is volatile metabolic signature that in recent literature is called “volatilome”. Volatile organic compounds (VOCs) from the headspace of cultured THP1 cells and normal human peripheral blood mononuclear cells, were collected by headspace solid-phase microextraction (HS-SPME) and analyzed by gas chromatography combined with …
Springer, Cham
Publication date: 
21 Feb 2017

A Forleo, S Capone, V Longo, F Casino, AV Radogna, P Siciliano, M Massaro, E Scoditti, N Calabriso, MA Carluccio

Biblio References: 
Pages: 269-277
AISEM Annual Conference on Sensors and Microsystems