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The ongoing nanotech revolution has the potential to transform diagnostic and therapeutic methods. Stimuli-triggered nanotherapies based on remotely activated agents have become attractive alternatives to conventional chemotherapy. Herein, we designed an optimized smart nanoplatform based on dually loaded hybrid liposomes to achieve enhanced tumor therapy. The aqueous core was highly loaded with iron oxide nanoparticles, while the lipid bilayer was supplied with a photosensitizer payload. The double cargo translated into double functionality: generation of singlet oxygen under laser excitation and heat production under alternating magnetic field stimulation, coupling photodynamic therapy (PDT) to magnetic hyperthermia (MHT). These liposomes address both therapeutic agents within tumor cells, and the combined PDT/MHT therapy resulted in complete cancer cell death in vitro while total solid-tumor …
American Chemical Society
Publication date: 
27 Feb 2015

Riccardo Di Corato, Gaëlle Béalle, Jelena Kolosnjaj-Tabi, Ana Espinosa, Olivier Clément, Amanda KA Silva, Christine Ménager, Claire Wilhelm

Biblio References: 
Volume: 9 Issue: 3 Pages: 2904-2916
ACS nano