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Recent advances in cell therapy and tissue engineering opened new windows for regenerative medicine, but still necessitate innovative noninvasive imaging technologies. We demonstrate that high-resolution magnetic resonance imaging (MRI) allows combining cellular-scale resolution with the ability to detect two cell types simultaneously at any tissue depth. Two contrast agents, based on iron oxide and gadolinium oxide rigid nanoplatforms, were used to “tattoo” endothelial cells and stem cells, respectively, with no impact on cell functions, including their capacity for differentiation. The labeled cells’ contrast properties were optimized for simultaneous MRI detection: endothelial cells and stem cells seeded together in a polysaccharide-based scaffold material for tissue engineering appeared respectively in black and white and could be tracked, at the cellular level, both in vitro and in vivo. In addition, endothelial …
American Chemical Society
Publication date: 
20 Aug 2013

Riccardo Di Corato, Florence Gazeau, Catherine Le Visage, Delphine Fayol, Pierre Levitz, François Lux, Didier Letourneur, Nathalie Luciani, Olivier Tillement, Claire Wilhelm

Biblio References: 
Volume: 7 Issue: 9 Pages: 7500-7512
ACS nano