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One of the major challenges of drug delivery is the development of suitable carriers for therapeutic molecules. In this work, a novel nanoformulation based on superparamagnetic nanoclusters [magnetic nanocrystal clusters (MNCs)] is presented. In order to control the size of the nanoclusters and the density of magnetic cores, several parameters were evaluated and tuned. Then, MNCs were functionalized with a polydopamine layer (MNC@PDO) to improve their stability in aqueous solution, to increase density of functional groups and to obtain a nanosystem suitable for drug-controlled release. Finally, cisplatin was grafted on the surface of MNC@PDO to exploit the system as a magnetic field-guided anticancer delivery system. The biocompatibility of MNC@PDO and the cytotoxic effects of MNC@PDO–cisplatin complex were determined against human cervical cancer (HeLa) and human breast adenocarcinoma …
American Chemical Society
Publication date: 
24 Dec 2018

Giacomo Mandriota, Riccardo Di Corato, Michele Benedetti, Federica De Castro, Francesco P Fanizzi, Rosaria Rinaldi

Biblio References: 
Volume: 11 Issue: 2 Pages: 1864-1875
ACS applied materials & interfaces