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Trifunctional polymer nanobeads are prepared by destabilization of a mixture of magnetic nanoparticles, quantum dots, and an amphiphilic polymer, followed by functionalization of the bead surface with folic acid molecules. The distribution of the nanoparticles within the nanobeads can be tuned using either acetonitrile or water as destabilizing solvent. The luminescence of the resulting beads can be tuned by varying the ratio of quantum dots per magnetic nanoparticles. The application of an external magnetic field (such as a small static magnet of 0.3 T) to the magnetic−fluorescent nanobeads allows the quantitative accumulation of the beads within a few hours depending on the total size of the beads. Furthermore, specific targeting of cancer cells overexpressing folate receptors is achieved thanks to the folic acid decorating the surface of the as-synthesized nanobeads. Folate receptor mediated cellular uptake of …
American Chemical Society
Publication date: 
10 Jan 2011

Riccardo Di Corato, Nadja C Bigall, Andrea Ragusa, Dirk Dorfs, Alessandro Genovese, Roberto Marotta, Liberato Manna, Teresa Pellegrino

Biblio References: 
Volume: 5 Issue: 2 Pages: 1109-1121
ACS nano