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Magnetic hyperthermia (MHT) and photothermal therapy (PTT) are emergent state‐of‐the‐art modalities for thermal treatment of cancer. While their mechanisms of action have distinct physical bases, both approaches rely on nanoparticle‐mediated remote onset of thermotherapy. Yet, are the two heating techniques interchangeable? Here, the heating obtained either with MHT or with PTT is compared. The heating is assessed in distinct environments and involves a set of nanomaterials differing in shape (spheres, cubes, stars, shells, and rods) as well as in composition (maghemite, magnetite, cobalt ferrite, and gold). The nanoparticle's heating efficacy in an aqueous medium is first evaluated. Subsequently, the heating efficiency within the cellular environment, where intracellular processing markedly decreases MHT, is compared. Conversely, endosomal sequestration could have a positive effect on PTT. Finally …
Publication date: 
1 Sep 2018

Ana Espinosa, Jelena Kolosnjaj‐Tabi, Ali Abou‐Hassan, Anouchka Plan Sangnier, Alberto Curcio, Amanda KA Silva, Riccardo Di Corato, Sophie Neveu, Teresa Pellegrino, Luis M Liz‐Marzán, Claire Wilhelm

Biblio References: 
Volume: 28 Issue: 37 Pages: 1803660
Advanced Functional Materials