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There is a great deal of interest in the development of nanoplatforms gathering versatility and multifunctionality. The strategy reported herein meets these requirements and further integrates a cell-friendly shell in a bio-inspired approach. By taking advantage of a cell mechanism of biomolecule transport using vesicles, we engineered a hybrid biogenic nanoplatform able to encapsulate a set of nanoparticles regardless of their chemistry or shape. As a proof of versatility, different types of hybrid nanovesicles were produced: magnetic, magnetic-metallic and magnetic-fluorescent vesicles, either a single component or multiple components, combining the advantageous properties of each integrant nanoparticle. These nanoparticle-loaded vesicles can be manipulated, monitored by MRI and/or fluorescence imaging methods, while acting as efficient nano-heaters. The resulting assets for targeting, imaging and therapy …
Royal Society of Chemistry
Publication date: 
1 Jan 2013

Amanda K Andriola Silva, Riccardo Di Corato, Teresa Pellegrino, Sophie Chat, Giammarino Pugliese, Nathalie Luciani, Florence Gazeau, Claire Wilhelm

Biblio References: 
Volume: 5 Issue: 23 Pages: 11374-11384