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Ubiquitous in nature, polyamines (PAs) are a class of low-molecular aliphatic amines critically involved in cell growth, survival and differentiation. The polycation behavior is validated as a successful strategy in delivery systems to enhance oligonucleotide loading and cellular uptake. In this study, the chemical features and the functional roles of the PA spermidine are synergistically exploited in the synthesis and bioactive functionalization of SiO 2-based structures. Inspired by biosilicification, the role of spermidine is assessed both as catalyst and template in a biomimetic one-pot synthesis of dense silica-based particles (SPs) and as a competitive agent in an interfacial reassembly strategy, to empty out SPs and generate spermidine-decorated hollow silica nanoporous pods (spd-SNPs). Spermidine bioactivity is then employed for targeting tumor cell over-expressed polyamine transport system (PTS) and for effective …
Nature Publishing Group
Publication date: 
3 Dec 2020

Giulia Della Rosa, Riccardo Di Corato, Sara Carpi, Beatrice Polini, Antonietta Taurino, Lorena Tedeschi, Paola Nieri, Rosaria Rinaldi, Alessandra Aloisi

Biblio References: 
Volume: 10 Issue: 1 Pages: 1-15
Scientific reports