-A A +A
The growing interest in multifunctional nano-objects based on polymers and magnetic nanoparticles for biomedical applications motivated us to develop a scale-up protocol to increase the yield of polymeric magnetic nanobeads while aiming at keeping the structural features at optimal conditions. The protocol was applied to two different types of magnetic ferrite nanoparticles: the Mn-ferrite selected for their properties as contrast agents in magnetic resonance imaging and iron oxide nanostar shaped nanoparticles chosen for their heat performance in magnetic hyperthermia. At the same time, some experiments on surface functionalization of nanobeads with amino modified polyethyelene glycol (PEG) molecules have provided further insight into the formation mechanism of magnetic nanobeads and the need to cross-link the polymer shell to improve the stability of the beads, making them more suitable for further …
American Chemical Society
Publication date: 
16 Dec 2022

Nadja C Bigall, Marina Rodio, Sahitya Avugadda, Manuel Pernia Leal, Riccardo Di Corato, John S Conteh, Romuald Intartaglia, Teresa Pellegrino

Biblio References: 
The Journal of Physical Chemistry A