Alzheimer’s Disease is a problem of social and economic relevance as it involves both patients and their families/caregivers. Presently no cure is available. In the treatment of this disease, cognitive rehabilitation appears as an attractive choice for patients with a mild form. The aim of this work is the design and the development of a remote system, called “Virtual Personal Trainer”, integrating advanced Natural User Interface technologies to support the patients during the rehabilitation process at home. The system allows both the autonomous execution of the required exercises and the data reporting and storing of the daily performance for every exercise. In this scenario, the patient avoids to physically move to a specialized center and the physician can use the platform in order to verify the response to the therapy and the compliance to the treatment.