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Oral cancer is one of the most common types of cancer in Europe and its large diffusion requires, together with prevention, the development of low-cost and reliable portable platforms for its diagnosis, with features of high selectivity and sensitivity. In this study, the development and characterization of a molecularly imprinted polymer (MIP)-based electrochemical sensor for TGF-β1 detection are reported. The optimized biosensor is a potential tool for the early screening of oral cancer. A biomimetic surface has been obtained by electropolymerization of o-phenylenediamine (o-PD) on platinum electrodes, in the presence of TGF-β1 as a template molecule. MIP synthesis, template removal and TGF-β1 rebinding have been monitored by Differential Pulse Voltammetry (DPV). Atomic Force Microscopy (AFM) has been performed to investigate and characterize the surface morphology and the influence of the washing step …
Royal Society of Chemistry
Publication date: 
1 Jan 2023

Giulia Siciliano, Maria Serena Chiriacò, Francesco Ferrara, Antonio Turco, Luciano Velardi, Maria Assunta Signore, Marco Esposito, Giuseppe Gigli, Elisabetta Primiceri

Biblio References: 
Volume: 148 Issue: 18 Pages: 4447-4455