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The combination of materials that possess different properties (such as, for instance, fluorescence and magnetism) into one single object of nanoscale size represents an attractive challenge for biotechnology, especially for their potential relevance in biomedical applications. We report here the preparation of novel bifunctional conjugates based on the linkage of inorganic nanoparticles to organic oligothiophene fluorophores (OTFs). In comparison to the organic dyes commonly used in bioimaging and more similarly to colloidal quantum dots, OTFs have broad optical absorption spectra, and therefore OTF fluorophores emitting at different colors can be excited with a single excitation source, allowing for easier multiplexing analysis. In this work we show the preparation of OTF−nanoparticle conjugates based on gold and iron oxide nanoparticles and their characterization using different techniques such as gel …
American Chemical Society
Publication date: 
16 Jul 2008

Alessandra Quarta, Riccardo Di Corato, Liberato Manna, Simona Argentiere, Roberto Cingolani, Giovanna Barbarella, Teresa Pellegrino

Biblio References: 
Volume: 130 Issue: 32 Pages: 10545-10555
Journal of the American Chemical Society