The project proposes a comprehensive preventive program of dementia in elderlies with minor cognitive disorders due to neurodegenerative diseases. The program combines physical and cognitive training, by means of an integrated technological system composed of a Virtual Environment, simulating daily activities, a smart garment measuring physiological parameters, a bicycle ergometer and tailoring the system to the specific patient’s status. Preliminary results confirm the feasibility of this intervention and appear promising in order to contrast age-related cognitive neurodegeneration.