In literature many examples of magnetic nanohybrids based on cyclodextrins are reported, but they often require multistep processes and preliminary synthetic efforts that affect the scale-up for the final application. In this paper, a magnetic hybrid system was produced by supramolecular self-assembly between low-cost precursors: the sulfobutylether-β-cyclodextrin (Captisol) and magnetic iron oxide-based nanoparticles (MNPs). The interaction between the Captisol and MNPs was elucidated by spectroscopic (Fourier Transform Infrared − FT-IR, X-ray Photoelectron Spectroscopy – XPS, micro X-ray fluorescence – μXRF) and imaging (Transmission Electron Microscopy − TEM) techniques. The resulting MNPs@Captisol assembly was also characterized by thermogravimetric analysis to establish the amount of the organic moiety. The colloidal features were evaluated by dynamic light scattering measurements and an …